Download Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Pdf

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 false
By:
Published on 2018 by

Abstract: Mirror-image pain (MIP), which occurs along with complex regional pain syndrome, rheumatoid arthritis and chronic migraine, is characterized by increased pain sensitivity of healthy body regions other than the actual injured or inflamed sites. A high level of peripheral inflammation may activate central or peripheral glia, triggering mirror-image pain. However, which receptors mediate inflammatory signals to contribute glial activation remains unclear. Intraplantarly injecting mice with 5-hydroxytryptamine (5-HT) or acidic buffer (proton) caused only unilateral hyperalgesia, but co-injection of 5-HT/acid induced bilateral hyperalgesia (MIP). Blocking 5-HT3 or acid-sensing ion channel 3 (ASIC3) abolished satellite glial activation, inhibiting MIP. Interestingly, intraplantar administration of a 5-HT3 agonist induced MIP, and 5-HT3 –mediated MIP can be reversed by a 5-HT3 antagonist or an ASIC3 blocker. Similar results were found using a ASIC3 agonist. Furthermore, 5-HT3 was observed to co-localize with ASIC3 in DRG neurons; 5-HT3 activation-induced an increase in intracellular calcium that was inhibited by an ASIC3 blocker and vice versa. A cross-talk between 5-HT3 and ASIC3 mediates satellite glial activation, thereby triggering mirror-image pain. Graphical abstract: Highlights: Peripheral 5-HT3 and ASIC3 are essential to mediate mirror-image pain through activation of satellite glial cells. 5-HT3 is cross-talked with ASIC3 to regulate downstream signaling that affecting activation of satellite glial cells. 5-HT2B -mediated an inhibitory signal to prevent 5-HT3 -mediated mirror-image pain.

This Book was ranked at 21 by Google Books for keyword Peripherals.

Book ID of Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3's Books is NOaOtQEACAAJ, Book which was written by have ETAG "oSiukKPrm9o"

Book which was published by since 2018 have ISBNs, ISBN 13 Code is and ISBN 10 Code is

Reading Mode in Text Status is false and Reading Mode in Image Status is false

Book which have " Pages" is Printed at BOOK under Category

Book was written in en

eBook Version Availability Status at PDF is falseand in ePub is false

Book Preview

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Free Download

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 PDF Free

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 PDF

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Free

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Books Free

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Audio Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 full-text Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Online Read

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Kindle

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Review

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Book Summary

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Book PDF

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 Book Review

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 - - Google Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by - Goodreads

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 - -

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 - -

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 E-Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by E-Books

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by ebooks

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by - Full Text Free Book - Full Text Archive

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by - Full Text Free Book

Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by - Full Text Archive

Amazon.com: Peripheral 5-HT3 Mediates Mirror-image Pain by a Cross-talk with Acid-sensing Ion Channel 3 by